About CKB

The Jackson Laboratory Clinical Knowledgebase (CKB) is a semi-automated/manually curated database of gene/variant annotations, therapy knowledge, diagnostic/prognostic information, and clinical trials related to oncology. CKB not only contains current information on the protein effect of somatic gene variants, but also connects the variant to targeted therapies through an efficacy evidence annotation. In addition, CKB captures clinical trial patient eligibility criteria that include genomic alterations (genotype-specific). The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, is designed to interrogate the knowledgebase for specific data attributes while also enabling a robust browse like feature when the desired content is unknown.

CKB Data Model Overview:

For additional information, please contact ckbsupport@jax.org

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Citations About:

Sara E. Patterson, Rangjiao Liu, Cara M. Statz, Daniel Durkin, Anuradha Lakshminarayana, and Susan M. Mockus. The Clinical Trial Landscape in Oncology and Connectivity of Somatic Mutational Profiles to Targeted Therapies. Human Genomics, 2016 Jan 16;10(1):4. (PMID: 26772741)

Citation Use Cases:

  • Sara E Patterson, Cara M Statz, Taofei Yin, Susan M Mockus. Utility of the JAX Clinical Knowledgebase in capture and assessment of complex genomic cancer data. NPJ Precision Oncology, 2019 Jan 15;3:2 (PMID: 30675517)
  • Kaisaki, Pamela J., Anthony Cutts, Niko Popitsch, Carme Camps, Melissa M. Pentony, Gareth Wilson, Suzanne Page, et al, Targeted Next-Generation Sequencing of Plasma DNA from Cancer Patients: Factors Influencing Consistency with Tumour DNA and Prospective Investigation of Its Utility for Diagnosis. PloS One 11, no. 9 (2016): e0162809. doi:10.1371/journal.pone.0162809. (PMID: 27626278)
  • C.M. Statz, S.E. Patterson, S.M. Mockus, mTOR Inhibitors in Castration-Resistant Prostate Cancer. Target Oncol., (2016), Aug 9 [Epub ahead of print]. (PMID: 27503005)
  • J.L. Dillon, S.M. Mockus, G. Ananda, V. Spotlow, W.A. Wells, G.J. Tsongalis, and J.D. Marotti. Somatic Gene Mutation Analysis of Triple Negative Breast Cancers. The Breast, 2016 Jul 7. (PMID: 27397723)
  • Susan M. Mockus, Sara E. Patterson, Cara Statz, Carol J. Bult, Gregory J. Tsongalis. Clinical Trials in Precision Oncology. Clinical Chemistry, 2016 Mar 62(3):442-8. (PMID: 26607725) Related podcast


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